TMPRSS2 is an endothelial cell surface protein that is involved in the viral entry and spread of coronaviruses including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the virus that ...

In a recent study posted to the bioRxiv* pre-print server, a team of researchers used an assay toolset for discovering new transmembrane protease serine 2 (TMPRSS2) inhibiting drug repurposing ...

HCoV-HKU1, one of seven human coronaviruses (HCoVs) that have harmful effects on human health, accounts for a substantial portion of common cold cases and can cause severe respiratory diseases in ...

TMPRSS2 is a host serine protease that helps influenza viruses and SARS-CoV-2 enter cells, making it an attractive target for antiviral intervention. Rather than blocking the protein after it is ...

How exactly do SARS-CoV-2 particles enter host cells? An international team led by Dr. Richard Brown from Dr. Daniel Todt's Computational Virology group at the Department of Molecular and Medical ...

Lymph-node (LN) metastasis in prostate cancer (PC) is a main risk factor for tumor recurrence after radical prostatectomy (RP). Molecular analysis facilitates detection of small-volume LN metastases ...

A common genetic change is associated with a reduced risk of severe COVID-19 infection, highlighting a potential target for drugs in early treatment. A team led by Imperial College London researchers ...

There are no therapeutics available that have been developed for COVID-19 treatment. Repurposing of already available medication for COVID-19 therapy is an attractive option to shorten the road to ...

Validation of a panel of cell-cycle progression genes for improved risk stratification in a contemporary radical prostatectomy cohort. Background: Approximately 50% of prostate cancers (PC) contain ...

Identifying a Clinically Applicable Mutational Burden Threshold as a Potential Biomarker of Response to Immune Checkpoint Therapy in Solid Tumors TMPRSS2-ERG gene fusions are frequently found in ...