In the earliest phase of creating human proteins, the protein complex NAC performs an essential task by starting the first steps toward folding proteins into their correct three-dimensional structures ...

Protein biogenesis at the endoplasmic reticulum requires translocons comprising the Sec61 protein-conducting channel and several dynamically associated accessory factors. Here we used ...

Most proteins act through interactions with other molecules, yet predicting how single mutations perturb these interactions—defined as ‘protein codes’—remains a central challenge in computational ...