The intrinsically disordered proteins (IDPs) do not attain a stable secondary or tertiary structure and rapidly change their conformation, making structure prediction particularly challenging. These ...

On Wednesday, the Nobel Committee announced that it had awarded the Nobel Prize in chemistry to researchers who pioneered major breakthroughs in computational chemistry. These include two researchers ...

Researchers have deposited over 6,300 protein structures in a freely available database. The models result from protein structure predictions completed by David Baker’s group at the University of ...

Proteins spontaneously fold into intricate three-dimensional shapes which are key to nearly every biological process. But the complexity of protein shapes makes them difficult to study. Recently, ...

Proteins are the molecular workhorses of cells. To understand their functions, scientists soon realized that they had to figure out proteins’ shapes. But solving a protein structure is a challenging ...

A research study describes a systematic high-throughput design approach for virtual screening and creation of novel polypeptide-based molecules that form regular secondary structures that can be used ...

To function correctly, cellular proteins depend not only on their complex tertiary and quaternary structures, but also on their proximity to and interactions with other molecules participating in the ...