Each year, 20 million people are diagnosed with cancer. Various organs can be affected, and cancer types sometimes differ ...

(TP53), widely known as the “guardian of the genome,” is one of the most frequently altered genes in human cancer. While its canonical tumor-suppressive ...

Molecular model of the tumor suppressor protein p53 (beige) bound to a molecule of DNA (red and blue). P53 maintains genomic stability by controlling cell division, repairing DNA damage, and ...

Researchers in the lab of Michael Sigal at the Max Delbrück Center and Charité – Universitätsmedizin Berlin have elucidated the role of the p53 gene in ulcerative colitis. The study, published in ...

Researchers showed that small engineered proteins can restore the function of mutated p53 by stabilizing its structure. The ...

Scientists from a German-Swiss consortium have developed miniature antibody-like proteins, called DARPins, that can stabilize and reactivate multiple mutated forms of the p53 tumor suppressor protein ...

Researchers at the University of Illinois Chicago have developed an anti-cancer therapy inspired by bacteria found in cancer ...

Anti-tumor effects of molecular glue BC. (a) Representative images of tumors in different treatment groups after 28 days. (b) Quantifications of anti-tumor activity of compound BC in the xenograft. (c ...

Trim24 regulates a subset of p53 target genes. a, Number and overlap of genes that change upon p53 activation compared with uninduced cells and upon Trim24 degradation in p53-active conditions. b, p53 ...

Researchers at the University of Illinois Chicago have developed an anti-cancer therapy inspired by bacteria found in cancer ...