New technology enables the insertion of a large segment of DNA into a genome, potentially expanding gene therapy treatment ...

Scientists have captured the most detailed structural images to date of a specific type of protein's DNA repair process, a ...

Everyday DNA mutations can help us understand immune function and aging—and even mitigate harm caused by some inherited ...

While most known types of DNA damage are fixed by our cells’ in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...

Cancer cells survive by repairing damage to their DNA—even damage that would normally be fatal. One of their most important ...

Scientists have corrected an extremely rare and life-threatening genetic disease of the liver in mouse models and human patient cells, using the gene-editing approach that served as the basis for the ...

The gene editing treatment targets the relatively common 1717-1G>A splicing mutation, which does not respond to many current ...

In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations in mitochondrial DNA using a genetic tool known as a base editor. The ...

A troubling new study from MIT reveals that a common environmental contaminant, NDMA—found in polluted water, certain medications, and even processed foods—may pose a far greater cancer risk to ...