Gain-of-function research (GOFR) refers to the serial passaging of microorganisms to increase their transmissibility, virulence, immunogenicity, and host tropism by applying selective pressure to a ...

In May 2025, President Donald Trump signed an executive order to restrict research on viruses and pathogens called gain-of-function studies. The National Institutes of Health is now taking steps to ...

Congress is considering a massive overhaul of the nation’s scientific enterprise, much of it in the name of ensuring competitiveness with China and other nations that are pouring billions into ...

Activists want it banned. The US government may soon further restrict it. And politicians won’t stop talking about it. So-called “gain-of-function” pathogen research has faced growing scrutiny ever ...

Due to unanswered questions into the origins of the coronavirus pandemic, both the U.S. government and scientists have called for a deeper examination into the validity of claims that a virus could ...

Proteoglycans are ubiquitous molecules that function as critical components of the extracellular matrix. These proteins are composed of glycosaminoglycan chains that are covalently attached to a ...