Cellular DNA is constantly subjected to threats, both from the environment via exposure to radiation or chemicals and as a consequence of natural cellular processes, e.g., the production of endogenous ...
Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...
Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...
PARP inhibitors (PARPi), known for their ability to induce replication gaps and accelerate replication forks, have become potent agents in anticancer therapy. However, the molecular mechanism ...
A new discovery by researchers at the RIKEN Center for Biosystems Dynamics (BDR) in Japan upends decades of assumptions regarding DNA replication. Led by Ichiro Hiratani and colleagues, the ...
Researchers shed new light on G-quadruplexes, a type of secondary DNA structure that has attracted attention as a potential therapeutic target in cancer. Every day, billions of cells in your body ...
In the DNA fiber assay used in this study, cells labeled with IdU (green) and CldU (red) nucleotide analogs were sorted into substages of S phase before being subjected to the DNA fiber assay. This ...
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