Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment ...

If you are anything like us, whenever you plan a journey, you spend a remarkable amount of time thinking about the start and ...

DNA replication in eukaryotic cells is a highly coordinated, multi-step process that ensures precise duplication of the genome prior to cell division. In late mitosis and early G1 phase, the Origin ...

Cyclin-dependent kinases (CDKs) coordinate DNA replication and cell division, and play key roles in tissue homeostasis, genome stability and cancer development. The first step in replication is origin ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular ageing, cancer, ...

DNA replication is the process by which a cell makes an identical copy of its DNA. This process is performed at the beginning of every cell division so that when the cell divides, each daughter cell ...

A representative figure showing that HELQ-deficient cells fail to undergo normal fork slowing after MMC (a crosslinking agent) treatment, consistent with defective fork reversal. Every time a cell ...

For almost 60 years, scientists have tried to understand why DNA doesn’t replicate wildly and uncontrollably every time a cell divides – which they need to do constantly. Without this process, we ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

Cold sore virus takes over human DNA within just one hour, study finds - Study is first to prove that herpes virus reshapes ...

DNA's iconic double helix does more than "just" store genetic information. Under certain conditions, it can temporarily fold into unusual shapes. Researchers at Umeå University, Sweden, have now shown ...

Researchers at Oregon Health & Science University have identified a previously unrecognised role for the cancer-associated ...