Together, these results reinforce the notion that PCNA and lagging-strand processes undergo functional exhaustion during unperturbed origin activation and become further depleted upon unscheduled ...
In eukaryotic cells, DNA polymerase (Pol) ε and Pol δ synthesize the leading and lagging strands, respectively 1,2. These enzymes work in the 5′-to-3′ direction, resulting in continuous replication of ...
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